Mass Effect 2. No question. If they just remade the first game, it would still be my game of show. It looks absolutly gorgeous, and all the gameplay I've seen has a very respectable framerate and a wonderfull vitality that the first one didn't have. Add in new species, new planets, new weapons, new vehicle, and so much more and I already know what will be my game of the year in '10. First runner up would probably be Splinter Cell: Conviction and then it's a close race between Just Cause 2 and Crackdown 2 (if I'd actually seen any gameplay for Crackdown, it wouldn't even be a question). Honorable mentions for Natal (a shame it is soooo far out), God of War 3, Assassins Creed 2 and Brutal Legend.
When I die, I want to go like grandpa, peacefully while I'm asleep. Not screaming like the other people in his car.