Hey there, just to let you guys know in case anyone is still trying for the achievements for this game, I've made videos of the 3 most difficult achievements of this game. I've also taken the opportunity to write some tips down for you as well. Here goes:

Run! achievement video.

Run! achievement tips:

To begin with, you want to just glide around idly, avoid any shots that might come in. One the mutants start to arrive (flashing enemies), you want to alternate going left and then right. This confuses them as they are programmed to choose the direction that results in the least distance travelled.
Finally, you've got to learn to avoid the baiter that spawns just towards the end. You can use a similar technique to avoid that but you might need some vertical movement as well.

Protect All Humans achievement video.

Protect All Humans achievement tips:

For the most part, you want to play as if it's a normal game. Try to protect the humans from the landers and not accidentally shoot any.
In levels 2 and 3, especially, move towards the sparkly star enemies (not sure of their name) and bomb them. In the later levels, this usually results in an extra life and bomb. Move quickly and in one direction, keep an eye on your map. If you hear a "squeak" of a human and you know you can't get to him within a second, run into an enemy and lose a life. If you can safely shoot the enemy and rescue the human (not let him hit the ground) or (less preferably) you can quickly dash and bomb the enemy, then that'll help.
Finally, it might take some practice to get, particularly to do it on the 3rd level but it'll happen with patience.

Five Waves achievement video.

Five Waves achievement tips:

Try to always ensure you have at least 1 human remaining at the bottom, carry one of them throughout the level if you have to, once the screen explodes, I don't rate your chances with a bunch of mutants flying around.
In addition, from level 3 onwards in particular, if you dash to where the star enemies are and bomb them WHILE moving, this will result in the destruction of them all and often give you an extra life. Doing it stationary will NOT guarantee their complete destruction! Aside from the baiters and a group of mutants, the small enemies that spawn from these are probably the hardest enemies in the game so you'll want to get rid of them straightaway. After that, it's just survival and making sure you have at least 1 bomb for emergencies.

Hope that these videos will help any of you still struggling with these achievements.

Good luck!

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