Simple.  What is the very worst thing to happen to your garden?

For me, it was when a Sour entered by garden and spitted out hemlock seeds.  By the time I noticed, there was hemlock all over a corner of my garden, and my pinatas were all sick.  To make matters worse, Professor Pester and a Ruffian came and added to my nightmare.  Dastardos also smashed about 10 of my pinatas open. 

In a desperate attempt to reserve my finances, I sold each of my healthy pinata.  To help with the weed problem, I hired 3 Weedlings (which didn't appear until the next day)

After the whole scenario, I was left with a few basic pinata and an unnecessary number of weedlings.  I effectively had to start over again.

So, what about you?  What was the worst thing to happen to your garden?

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"If everything seems to be going well, you have obviously overlooked something"

for me it was when the giant snail came out of the mine and covered all of my grass in slime which meant I couldn't plant or grow anything. I had to dig out mky whole garden.

I stopped playing it after that

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GTA4 was the worst game of 2008.