I've got that annoying audio problem too:loud schrieking noise from the speakers during dialog sometimes.
And now I seem to be stuck in a loop during the game. I'm trying to leave Peragus in the Ebon Hawk, but the screen won't go further. I can only see Atton punching the buttons and that's it. He's been punching those buttons for over an hour now. Funny.
I'll try playing with my profile online. Let's see if that helps.
I encourage anyone with the audio problem to add to this thread.
-What are you doing here, Spike? Five words or less!
-Out..for...a...walk....B**tch!