Uhhh.... I'm deleting everything off of my hard drive since none of it is every going to see the light of day again.
But, if you are concerned, there are a few game patches you can delete, such as the first couple HUGE Gig+ patches for BF3.
You could also consider deleting older games from your hard drive, also freeing up space. (but you'll still have the disks to play old games from) etc.